SCREENING METHODS: Antibacterial activity

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Antibacterial activity

The best example of this is tea tree oil, which has been shown to have excellent activity in vitro against the fungi responsible for various tinea’s (MIC 0.004-0.06%) (Hammer et al, 2002) yet the results from clinical trials have been far from conclusive (Satchell et al, 2000). This illustrates the caution with which researchers should view results from in vitro assays and reinforces the need for clinical trials of plant extracts that show therapeutic promise.

In vivo antibacterial activity: Five groups of Albino mice were used in this experiment. The selected test organism was cultured overnight at 37 °C on nutrient agar. The organism was harvested and suspended in sterile saline and each mouse was challenged intraperitoneally with a single 0.5 mL portion of bacterial suspension containing105 cfu of the desired bacterial sample per ml. This inoculum was sufficient to cause 100% mortality in untreated mice with death occurring between 6 and 10 h after challenge. 5.0, 10.0, 20.0, 25.0, 30.0, 35.0, 40.0, 45.0, 50.0, 100.0 and 200.0 mg/kg of plant extracts were administered subcutaneously 15 min after bacterial challenge. The total number of mice surviving at each dose level was recorded on day 7 after infection. The length of time before the death of each infected animal was also noted.

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